(Louis Pasteur, while experimenting)= in-article photo caption Considering that the technique can be applied for the prevention of other diseases, Louis Pasteur enabled the development of a vaccine for anthrax successfully used in sheep, goats and cows in 1881. Then, in 1885, when examining rabies disease, he injected the rabies-causing virus into rabbits and then isolated the spinal fluid to produce rabies vaccine from weakened (virulence reduced) viruses. After successfully protecting the dogs from disease, Pasteur agreed to treat the first human patient, a nine-year-old boy was attacked very violently by wild dogs, if nothing was done he would be left to die. Pasteur injected the child with more and more virulent doses of vaccine daily from rabies-infected rabbits. The child has never developed symptoms of rabies and has recovered. Pasteur became an international hero with the discovery of rabies vaccine. Obtaining the rabies vaccine and its application to patients was originally called the “treatment of Pasteur”. Pasteur developed the concepts of vaccine and vaccination in the honor of 18th century virology pioneer Edward Jenner, who found the treatment of smallpox for the first time, using the word “vaccine”, to develop vaccines “to increase immunity and prevent infectious disease. (usually weakened) or inactivated microorganisms (such as bacteria or viruses) or their fractions ”. The work of Louis Pasteur (1822-1895) enabled virology to become a science, promoting vaccine research all over the world. In later years, diphtheria (1888), plague (1897), tuberculosis (1927), yellow fever (1936), measles (1963), mumps (1963, 1967), rubella (1969), chicken pox (1995) and intestinal inflammation in children, the rotavirus (1998). Especially the second half of the 20th century was very effective in terms of vaccine R&D studies and prevention of deadly child diseases has been one of the greatest success stories of the last century. Methods of growing viruses in the laboratory have led to rapid discoveries and innovations, including the creation of vaccines for polio. In contemporary literature, vaccines are attenuated (live) vaccines (flower, chicken pox, rotavirus, yellow fever), inactivated vaccines (rabies, polio, hepatitis A), inactivated toxin vaccines (diphtheria, tetanus), conjugated vaccines (Hepatitis B, Pneumonia, The flue, HIV). The purpose of all vaccines is to elicit an immune response in the body against an antigen so that when the individual is exposed to the antigen again, they can show a much stronger secondary immune response. Vaccination has significantly reduced disability and death from infectious diseases in most of the developed world. For example, a smallpox vaccine. It is calculated that if it were not discovered and applied by Dr. Jenner massively, approximately 5 million people would die every year, and that 150 to 200 million lives have been saved from 1979, when the smallpox ended with the vaccine. Prof. Dr. Nihal Sarıer İKU Vice-Chancellor |